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Targeted Allele Detail
Symbol: Cyp26a1tm1.1Hmd
Name: cytochrome P450, family 26, subfamily a, polypeptide 1; targeted mutation 1.1, Hiroshi Hamada
MGI ID: MGI:2183292
Synonyms: CYP26-
Gene: Cyp26a1  Location: Chr19:37697798-37701536 bp, + strand  Genetic Position: Chr19, 32.36 cM, cytoband C2-C3
Germline Transmission:  Earliest citation of germline transmission: J:67375
Parent Cell Line:  R1 (ES Cell)
Strain of Origin:  (129X1/SvJ x 129S1/Sv)F1-Kitl+
Allele Type:    Targeted (Null/knockout)
Mutation:    Intragenic deletion
Mutation detailsThis allele is a derivative of Cyp26a1tm1Hmd in which the loxP flanked sequences were deleted in ES cells prior to the production of chimeric mice. All coding sequences of the gene were deleted. (J:67375)
View phenotypes and curated references for all genotypes (concatenated display).
In Structures Affected by this Mutation: 10 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 3 strains available      Cell Lines: 0 lines available
Carrying any Cyp26a1 Mutation:  18 strains or lines available
Original:  J:67375 Sakai Y, et al., The retinoic acid-inactivating enzyme CYP26 is essential for establishing an uneven distribution of retinoic acid along the anterio-posterior axis within the mouse embryo. Genes Dev. 2001 Jan 15;15(2):213-25
All:  6 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
MGI 6.14
The Jackson Laboratory