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Targeted Allele Detail
Symbol: Nkx3-2tm1Tno
Name: NK3 homeobox 2; targeted mutation 1, Tetsuo Noda
MGI ID: MGI:2183276
Synonyms: Bapx1-, Bapx-1LacZ
Gene: Nkx3-2  Location: Chr5:41761483-41764220 bp, - strand  Genetic Position: Chr5, 22.58 cM
Germline Transmission:  Earliest citation of germline transmission: J:77612
Parent Cell Line:  J1 (ES Cell)
Strain of Origin:  129S4/SvJae
Allele Type:    Targeted (Null/knockout, Reporter)
Mutations:    Insertion, Intragenic deletion
Mutation detailsThe entire coding region, spanning exons 1 and 2, was replaced with a cassette containing an NLS-lacZ gene and a floxed neo gene. The cassette was inserted at the translational start codon, which enabled expression of beta-galactosidase from the endogenous promoter. Northern blot analysis of total RNA obtained from homozygous mutant embryos showed a lack of transcript. (J:77612)
View phenotypes and curated references for all genotypes (concatenated display).
In Structures Affected by this Mutation: 22 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Nkx3-2 Mutation:  15 strains or lines available
Original:  J:77612 Akazawa H, et al., Targeted disruption of the homeobox transcription factor Bapx1 results in lethal skeletal dysplasia with asplenia and gastroduodenal malformation. Genes Cells. 2000 Jun;5(6):499-513
All:  1 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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MGI 6.15
The Jackson Laboratory