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Targeted Allele Detail
Symbol: Calrtm1Star
Name: calreticulin; targeted mutation 1, Rene St-Arnaud
MGI ID: MGI:2183263
Synonyms: CRT-
Gene: Calr  Location: Chr8:84842088-84846931 bp, - strand  Genetic Position: Chr8, 41.21 cM
Germline Transmission:  Earliest citation of germline transmission: J:61550
Parent Cell Line:  R1 (ES Cell)
Strain of Origin:  (129X1/SvJ x 129S1/Sv)F1-Kitl+
Allele Type:    Targeted (Null/knockout)
Mutation:    Insertion
Mutation detailsThe gene was disrupted by insertion of a reverse-facing PGK-neo cassette into exon 1 via homologous recombination. Southern blot analysis detected homozygous mutant embryos up to E14.5. Western blot analysis of E14.5 homozygous mutant embryos verified the absence of gene expression. (J:61550)
View phenotypes and curated references for all genotypes (concatenated display).
In Structures Affected by this Mutation: 6 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Calr Mutation:  11 strains or lines available
Original:  J:61550 Rauch F, et al., Heart, brain, and body wall defects in mice lacking calreticulin. Exp Cell Res. 2000 Apr 10;256(1):105-11
All:  2 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
MGI 6.15
The Jackson Laboratory