Upk3a^tm1Tsun
Targeted Allele Detail

Summary

• Symbol: Upk3a^tm1Tsun
• Name: uroplakin 3A; targeted mutation 1, Tung-Tien Sun
• MGI ID: MGI:2183244
• Synonyms: UPIII(-)
• Gene: Upk3a Location: Chr15:84901342-84906748 bp, + strand Genetic Position: Chr15, 40.25 cM, cytoband E3
• Alliance: Upk3a^tm1Tsun page

Urothelium lacks the umbrella cells and is leaky in Upk3a^tm1Tsun/Upk3a^tm1Tsun mice

Show the 5 phenotype image(s) involving this allele.

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:77653
• Parent Cell Line: W4 (ES Cell)
• Strain of Origin: 129S6/SvEvTac

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A neomycin selection cassette replaced the first exon and introduced a frameshift mutation that affected the remaining exons. Neither transcript nor protein was detected in homozygous mutant mice via Northern blot and Western blot analyses. (J:77653)

Disease models

Expression

In Structures Affected by this Mutation:

5 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Upk3a Mutation: 22 strains or lines available

References

• Original: J:77653 Hu P, et al., Ablation of uroplakin III gene results in small urothelial plaques, urothelial leakage, and vesicoureteral reflux. J Cell Biol. 2000 Nov 27;151(5):961-72
• All: 3 reference(s)