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Nrp2tm1Mkl
Targeted Allele Detail
Nomenclature
Symbol: Nrp2tm1Mkl
Name: neuropilin 2; targeted mutation 1, Michael Klagsbrun
MGI ID: MGI:2183238
Synonyms: NP2-, Nrp2 KO, Nrp2-lacZ
Gene: Nrp2  Location: Chr1:62703317-62818692 bp, + strand  Genetic Position: Chr1, 31.35 cM, cytoband C2
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:75477
Parent Cell Line:  Not Specified (ES Cell)
Strain of Origin:  Not Specified
Mutation
description
Allele Type:    Targeted (Null/knockout, Reporter)
Mutations:    Insertion, Intragenic deletion
 
Mutation detailsExon 1 and part of the downstream intron were replaced with a lacZ-neo cassette via homologous recombination. Northern blot analysis using a cDNA probe to nucleotides 15-620 confirmed the absence of gene expression in E9.5 homozygous mutant embryos. (J:75477)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Expression
In Mice Carrying this Mutation: 1 assay results
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Nrp2 Mutation:  28 strains or lines available
References
Original:  J:75477 Takashima S, et al., Targeting of both mouse neuropilin-1 and neuropilin-2 genes severely impairs developmental yolk sac and embryonic angiogenesis. Proc Natl Acad Sci U S A. 2002 Mar 19;99(6):3657-62
All:  10 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
10/08/2019
MGI 6.14
The Jackson Laboratory