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Targeted Allele Detail
Symbol: Tacr1tm1Rhn
Name: tachykinin receptor 1; targeted mutation 1, Rene Hen
MGI ID: MGI:2183231
Gene: Tacr1  Location: Chr6:82402334-82560104 bp, + strand  Genetic Position: Chr6, 35.94 cM, cytoband D1
Germline Transmission:  Earliest citation of germline transmission: J:77640
Parent Cell Line:  Not Specified (ES Cell)
Strain of Origin:  129S/SvEv
Allele Type:    Targeted (Null/knockout)
Mutation:    Insertion
Mutation detailsA neomycin selection cassette was inserted at the translational start codon, resulting in the deletion of the first two transmembrane domains. The absence of encoded protein was determined by in situ hybridization and immunohistochemistry. (J:77640)
View phenotypes and curated references for all genotypes (concatenated display).
In Structures Affected by this Mutation: 1 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Tacr1 Mutation:  23 strains or lines available
Original:  J:77640 Santarelli L, et al., Genetic and pharmacological disruption of neurokinin 1 receptor function decreases anxiety-related behaviors and increases serotonergic function. Proc Natl Acad Sci U S A. 2001 Feb 13;98(4):1912-7
All:  2 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
MGI 6.14
The Jackson Laboratory