Ror1^tm1Ymi
Targeted Allele Detail

Summary

• Symbol: Ror1^tm1Ymi
• Name: receptor tyrosine kinase-like orphan receptor 1; targeted mutation 1, Yasuhiro Minami
• MGI ID: MGI:2183224
• Synonyms: mRor1^-
• Gene: Ror1 Location: Chr4:99952988-100301962 bp, + strand Genetic Position: Chr4, 45.71 cM, cytoband C6
• Alliance: Ror1^tm1Ymi page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:72948
• Parent Cell Line: E14 (ES Cell)
• Strain of Origin: 129P2/OlaHsd

Mutation description

• Allele Type: Targeted
• Mutations: Insertion, Intragenic deletion
• Mutation details: The gene was disrupted by replacement of the coding exon with a neomycin resistance gene via homologous recombination. Western blot analysis detected a nearly full length protein in neural progenitor cells from homozygous mice. (J:72948, J:182150)

Expression

In Structures Affected by this Mutation:

4 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Ror1 Mutation: 57 strains or lines available

References

• Original: J:72948 Nomi M, et al., Loss of mRor1 Enhances the Heart and Skeletal Abnormalities in mRor2-Deficient Mice: Redundant and Pleiotropic Functions of mRor1 and mRor2 Receptor Tyrosine Kinases. Mol Cell Biol. 2001 Dec;21(24):8329-35
• All: 7 reference(s)