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Fut2tm1Sdo
Targeted Allele Detail
Nomenclature
Symbol: Fut2tm1Sdo
Name: fucosyltransferase 2; targeted mutation 1, Steven E Domino
MGI ID: MGI:2183220
Synonyms: FUT2-, Fut2-LacZ
Gene: Fut2  Location: Chr7:45648591-45666394 bp, - strand  Genetic Position: Chr7, 29.41 cM
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:72946
Parent Cell Line:  Pat5 (ES Cell)
Strain of Origin:  129X1/SvJ
Mutation
description
Allele Type:    Targeted (Null/knockout, Reporter)
Mutations:    Insertion, Intragenic deletion
 
Mutation detailsMost of the single coding exon of the gene was replaced with a lacZ-PGK-neo cassette via homologous recombination resulting in deletion of the catalytic domain. Homozygous mutant animals were identified by Southern blot and PCR genotype analysis. (J:72946)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Expression
In Structures Affected by this Mutation: 1 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Fut2 Mutation:  13 strains or lines available
Notes
The embryonic stem cell lines Pat5 and R1 were used for gene targeting.
References
Original:  J:72946 Domino SE, et al., Deficiency of Reproductive Tract alpha(1,2)Fucosylated Glycans and Normal Fertility in Mice with Targeted Deletions of the FUT1 or FUT2 alpha(1,2)Fucosyltransferase Locus. Mol Cell Biol. 2001 Dec;21(24):8336-45
All:  16 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
03/30/2021
MGI 6.16
The Jackson Laboratory