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Gfaptm1Ldtk
Targeted Allele Detail
Nomenclature
Symbol: Gfaptm1Ldtk
Name: glial fibrillary acidic protein; targeted mutation 1, Wolfgang Liedtke
MGI ID: MGI:2183213
Synonyms: GFAP-
Gene: Gfap  Location: Chr11:102887336-102897200 bp, - strand  Genetic Position: Chr11, 66.48 cM, cytoband D
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:77630
Parent Cell Line:  E14.1 (ES Cell)
Strain of Origin:  129P2/OlaHsd
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutation:    Insertion
 
Mutation detailsA frameshift mutation, resulting from the insertion of a neomycin selection cassette into exon 1, introduced a stop codon at position 44. The absence of encoded protein in homozygous mutant mice was determined by Western blot analysis. (J:77630)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Expression
In Structures Affected by this Mutation: 4 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Gfap Mutation:  22 strains or lines available
References
Original:  J:77630 Liedtke W, et al., GFAP is necessary for the integrity of CNS white matter architecture and long-term maintenance of myelination. Neuron. 1996 Oct;17(4):607-15
All:  1 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
05/19/2020
MGI 6.15
The Jackson Laboratory