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Targeted Allele Detail
Symbol: Ucp3tm1Brnd
Name: uncoupling protein 3 (mitochondrial, proton carrier); targeted mutation 1, Martin D Brand
MGI ID: MGI:2183204
Gene: Ucp3  Location: Chr7:100472990-100486432 bp, + strand  Genetic Position: Chr7, 54.36 cM
Germline Transmission:  Earliest citation of germline transmission: J:78047
Parent Cell Line:  Not Specified (ES Cell)
Strain of Origin:  Not Specified
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
Mutation details2.5 kb of sequence, including exons 1 and 2, was deleted and replaced by a neomycin selection cassette. The absence of transcript and protein was confirmed via Northern blot analysis of skeletal muscle RNA and Western blot analysis of mitochondria, respectively. (J:78047)
View phenotypes and curated references for all genotypes (concatenated display).
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Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Ucp3 Mutation:  1 strain or line available
Original:  J:78047 Echtay KS, et al., Superoxide activates mitochondrial uncoupling proteins. Nature. 2002 Jan 3;415(6867):96-9
All:  4 reference(s)

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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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MGI 6.12
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