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Targeted Allele Detail
Symbol: Ucp3tm1Lowl
Name: uncoupling protein 3 (mitochondrial, proton carrier); targeted mutation 1, Bradford B Lowell
MGI ID: MGI:2183166
Gene: Ucp3  Location: Chr7:100122198-100135639 bp, + strand  Genetic Position: Chr7, 54.36 cM
Germline Transmission:  Earliest citation of germline transmission: J:62313
Parent Cell Line:  J1 (ES Cell)
Strain of Origin:  129S4/SvJae
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
Mutation detailsA 700 bp genomic fragment containing part of exons 2 and 3 was replaced with a neomycin selection cassette. RNase protection analysis on RNA derived from skeletal muscle and brown adipose tissue of homozygous mice confirmed that no detectable transcript was expressed from this allele. Western blot analysis confirmed the absence of detectable protein in skeletal muscle mitochondria of homozygous mice. (J:62313)
View phenotypes and curated references for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Ucp3 Mutation:  3 strains or lines available
Original:  J:62313 Vidal-Puig AJ, et al., Energy metabolism in uncoupling protein 3 gene knockout mice. J Biol Chem. 2000 May 26;275(21):16258-66
All:  7 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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MGI 6.17
The Jackson Laboratory