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Ephb4tm1And
Targeted Allele Detail
Nomenclature
Symbol: Ephb4tm1And
Name: Eph receptor B4; targeted mutation 1, David J Anderson
MGI ID: MGI:2183162
Synonyms: EphB4taulacZ
Gene: Ephb4  Location: Chr5:137350109-137378669 bp, + strand  Genetic Position: Chr5, 76.38 cM
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:57908
Parent Cell Line:  AB1 (ES Cell)
Strain of Origin:  129S7/SvEvBrd-Hprt+
Mutation
description
Allele Type:    Targeted (Null/knockout, Reporter)
Mutations:    Insertion, Intragenic deletion
 
Mutation detailsA tau-lacZ-PGK-neo cassette replaced exon 1 and was fused in frame to the translation start codon via homologous recombination. Homozygous mutant embryos were identified by PCR genotyping at E9.5. (J:57908)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Expression
In Mice Carrying this Mutation: 46 assay results
In Structures Affected by this Mutation: 4 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Ephb4 Mutation:  1 strain or line available
References
Original:  J:57908 Gerety SS, et al., Symmetrical mutant phenotypes of the receptor EphB4 and its specific transmembrane ligand ephrin-B2 in cardiovascular development. Mol Cell. 1999 Sep;4(3):403-14
All:  24 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
10/09/2018
MGI 6.12
The Jackson Laboratory