Snai1^tm1Grid
Targeted Allele Detail

Summary

• Symbol: Snai1^tm1Grid
• Name: snail family zinc finger 1; targeted mutation 1, Tom Gridley
• MGI ID: MGI:2183156
• Synonyms: Sna^-, Snai1^del1, Snai1^null, Sna^tm1Grid
• Gene: Snai1 Location: Chr2:167380115-167384734 bp, + strand Genetic Position: Chr2, 87.33 cM
• Alliance: Snai1^tm1Grid page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:72861
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: Not Specified

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: Exons 1 and 2 encoding amino acids 1-203, which includes the translation start codon, degenerate zinc finger 1, and zinc fingers 2 and 3 of the DNA binding domain, were replaced with a neomycin resistance gene via homologous recombination. Homozygous mutant embryos were observed by genotype analysis at E6.5-E7.5. (J:72861)

Expression

In Mice Carrying this Mutation:	88 assay results
In Structures Affected by this Mutation:	6 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Snai1 Mutation: 9 strains or lines available

References

• Original: J:72861 Carver EA, et al., The mouse snail gene encodes a key regulator of the epithelial-mesenchymal transition. Mol Cell Biol. 2001 Dec;21(23):8184-8
• All: 10 reference(s)