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Snai1tm1Grid
Targeted Allele Detail
Nomenclature
Symbol: Snai1tm1Grid
Name: snail family zinc finger 1; targeted mutation 1, Tom Gridley
MGI ID: MGI:2183156
Synonyms: Sna-, Snai1del1, Snai1null, Snatm1Grid
Gene: Snai1  Location: Chr2:167538195-167542814 bp, + strand  Genetic Position: Chr2, 87.33 cM
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:72861
Parent Cell Line:  Not Specified (ES Cell)
Strain of Origin:  Not Specified
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
 
Mutation detailsExons 1 and 2 encoding amino acids 1-203, which includes the translation start codon, degenerate zinc finger 1, and zinc fingers 2 and 3 of the DNA binding domain, were replaced with a neomycin resistance gene via homologous recombination. Homozygous mutant embryos were observed by genotype analysis at E6.5-E7.5. (J:72861)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Expression
In Mice Carrying this Mutation: 88 assay results
In Structures Affected by this Mutation: 6 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Snai1 Mutation:  2 strains or lines available
References
Original:  J:72861 Carver EA, et al., The mouse snail gene encodes a key regulator of the epithelial-mesenchymal transition. Mol Cell Biol. 2001 Dec;21(23):8184-8
All:  8 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
03/03/2020
MGI 6.15
The Jackson Laboratory