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Nfatc4tm1Grc
Targeted Allele Detail
Summary
Symbol: Nfatc4tm1Grc
Name: nuclear factor of activated T cells, cytoplasmic, calcineurin dependent 4; targeted mutation 1, Gerald R Crabtree
MGI ID: MGI:2183093
Synonyms: c4-, NFATc4-
Gene: Nfatc4  Location: Chr14:56062252-56071400 bp, + strand  Genetic Position: Chr14, 28.19 cM, cytoband C1
Alliance: Nfatc4tm1Grc page
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:70266
Parent Cell Line:  Not Specified (ES Cell)
Strain of Origin:  129S/SvEv
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
 
Mutation detailsExons 1-2 and part of exon 3 were replaced with neomycin resistance gene via homologous recombination. This region of the gene encodes amino acids 1-413 and contains the translation start site, a regulatory domain that controls calmodulin-dependent cytoplasmic-to-nuclear translocation, and part of the DNA-binding domain. Western blot and RNase protection assay of homozygous mutant embryos verified the absence of gene expression. (J:70266)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Disease models
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Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Nfatc4 Mutation:  36 strains or lines available
References
Original:  J:70266 Graef IA, et al., Signals transduced by Ca(2+)/calcineurin and NFATc3/c4 pattern the developing vasculature. Cell. 2001 Jun 29;105(7):863-75
All:  10 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
03/19/2024
MGI 6.23
The Jackson Laboratory