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B3galnt1tm1Led
Targeted Allele Detail
Nomenclature
Symbol: B3galnt1tm1Led
Name: UDP-GalNAc:betaGlcNAc beta 1,3-galactosaminyltransferase, polypeptide 1; targeted mutation 1, Philip Leder
MGI ID: MGI:2183036
Synonyms: Brainiac 1 null
Gene: B3galnt1  Location: Chr3:69574158-69598960 bp, - strand  Genetic Position: Chr3, 32.24 cM
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:70591
Parent Cell Line:  TC1/TC-1 (ES Cell)
Strain of Origin:  129S6/SvEvTac
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutation:    Insertion
 
Mutation detailsThe gene was disrupted by insertion of a PGK-neo cassette 140 bp downstream of the ATG start codon via homologous recombination, resulting in the deletion of the entire C-terminal region after amino acid 47 in the encoded protein. Genotype analysis detected homozygous mutant embryos at 3.5 days post coitum. No homozygous mutant animals could be recovered. (J:70591)
Phenotypes
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Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any B3galnt1 Mutation:  8 strains or lines available
References
Original:  J:70591 Vollrath B, et al., A Murine Homologue of the Drosophila brainiac Gene Shows Homology to Glycosyltransferases and Is Required for Preimplantation Development of the Mouse. Mol Cell Biol. 2001 Aug;21(16):5688-97
All:  1 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
07/19/2016
MGI 6.04
The Jackson Laboratory