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Cacna1gtm1Hssh
Targeted Allele Detail
Nomenclature
Symbol: Cacna1gtm1Hssh
Name: calcium channel, voltage-dependent, T type, alpha 1G subunit; targeted mutation 1, Hee-Sup Shin
MGI ID: MGI:2182962
Synonyms: alpha1G-, Cav3.1-
Gene: Cacna1g  Location: Chr11:94408391-94474198 bp, - strand  Genetic Position: Chr11, 58.9 cM
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:70557
Parent Cell Line:  J1 (ES Cell)
Strain of Origin:  129S4/SvJae
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
 
Mutation detailsThe exon encoding N-terminal residues 82-118 was replaced with a neomycin resistance gene via homologous recombination. Western blot analysis of brain membrane fractions from homozygous mutant animals did not detect protein product. Whole cell voltage clamp analysis of thalamocortical relay neurons from homozygous mutants detected no calcium current thus confirming the functional ablation of the protein. (J:70557)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Disease models
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Expression
In Structures Affected by this Mutation: 5 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Cacna1g Mutation:  60 strains or lines available
References
Original:  J:70557 Kim D, et al., Lack of the burst firing of thalamocortical relay neurons and resistance to absence seizures in mice lacking alpha(1G) T-type Ca(2+) channels. Neuron. 2001 Jul 19;31(1):35-45
All:  27 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
09/10/2019
MGI 6.14
The Jackson Laboratory