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Elk3tm1Wlyk
Targeted Allele Detail
Nomenclature
Symbol: Elk3tm1Wlyk
Name: ELK3, member of ETS oncogene family; targeted mutation 1, Bohdan Wasylyk
MGI ID: MGI:2182950
Synonyms: netdelta, Netmutant
Gene: Elk3  Location: Chr10:93247414-93311135 bp, - strand  Genetic Position: Chr10, 48.04 cM, cytoband C-D1
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:71816
Parent Cell Line:  D4 (ES Cell)
Strain of Origin:  129/Sv
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
 
Mutation detailsExon 2, which encodes the first 69 amino acids (including the initiator methionine), and surrounding intronic sequence were replaced with a neomycin selection cassette. RT-PCR and sequence analysis showed the presence of an aberrantly spliced transcript in which exon 1 had joined exon 3. The aberrant transcript was shown by Western blot analysis to produce a 37kDa protein via an in-frame translational start site at nucleotide 571 (aa 93). The mutant protein lacks the Ets DNA-binding domain. (J:71816)
Phenotypes
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View phenotypes for all genotypes (concatenated display).
Disease models
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Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Elk3 Mutation:  6 strains or lines available
References
Original:  J:71816 Ayadi A, et al., Net-targeted mutant mice develop a vascular phenotype and up-regulate egr-1. EMBO J. 2001 Sep 17;20(18):5139-52
All:  5 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
06/23/2015
MGI 5.22
The Jackson Laboratory