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Efna2tm1Jgf
Targeted Allele Detail
Summary
Symbol: Efna2tm1Jgf
Name: ephrin A2; targeted mutation 1, John G Flanagan
MGI ID: MGI:2182943
Synonyms: A2-, ephrin-A2-
Gene: Efna2  Location: Chr10:80015316-80025844 bp, + strand  Genetic Position: Chr10, 39.72 cM
Alliance: Efna2tm1Jgf page
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:61499
Parent Cell Line:  TC1/TC-1 (ES Cell)
Strain of Origin:  129S6/SvEvTac
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutation:    Insertion
 
Mutation detailsA neomycin selection cassette, containing stop codons in all three reading frames, was inserted after the sequence encoding amino acid 66. The insertion was upstream of a conserved cysteine residue motif. RT-PCR analysis of midbrain RNA showed an absence of transcript in homozygous mutant embryos. (J:61499)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Disease models
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Expression
In Structures Affected by this Mutation: 2 anatomical structure(s)
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Efna2 Mutation:  17 strains or lines available
References
Original:  J:61499 Feldheim DA, et al., Genetic analysis of ephrin-A2 and ephrin-A5 shows their requirement in multiple aspects of retinocollicular mapping. Neuron. 2000 Mar;25(3):563-74
All:  34 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
04/16/2024
MGI 6.23
The Jackson Laboratory