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Targeted Allele Detail
Symbol: Mtf1tm1Wsc
Name: metal response element binding transcription factor 1; targeted mutation 1, Walter Schaffner
MGI ID: MGI:2182939
Synonyms: MTF-1-
Gene: Mtf1  Location: Chr4:124696342-124743593 bp, + strand  Genetic Position: Chr4, 57.91 cM, cytoband D1
Germline Transmission:  Earliest citation of germline transmission: J:48216
Parent Cell Line:  GS1 (ES Cell)
Strain of Origin:  129/Sv
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
Mutation detailsA neomycin selection cassette replaced sequences encoding the first two and a portion of the third zinc-finger domain. RT-PCR analysis of RNA from mutant embryos revealed the presence of an amino-terminal fragment, truncating 39 base pairs downstream of the 5' insertion point. The truncated transcript lacks sequence encoding 3 zinc-finger domains and the acidic, proline-rich, and serine/threonine-rich regions. (J:19100, J:48216)
View phenotypes and curated references for all genotypes (concatenated display).
In Mice Carrying this Mutation: 28 assay results
In Structures Affected by this Mutation: 1 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Mtf1 Mutation:  27 strains or lines available
Original:  J:48216 Gunes C, et al., Embryonic lethality and liver degeneration in mice lacking the metal-responsive transcriptional activator MTF-1. EMBO J. 1998 May 15;17(10):2846-54
All:  6 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
MGI 6.17
The Jackson Laboratory