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Targeted Allele Detail
Symbol: F2rl3tm1Cgh
Name: coagulation factor II (thrombin) receptor-like 3; targeted mutation 1, Shaun R Coughlin
MGI ID: MGI:2182916
Synonyms: Par4-
Gene: F2rl3  Location: Chr8:72761880-72763874 bp, + strand  Genetic Position: Chr8, 35.08 cM, cytoband B3.3
Germline Transmission:  Earliest citation of germline transmission: J:71391
Parent Cell Line:  RF8 (ES Cell)
Strain of Origin:  129S4/SvJae
Allele Type:    Targeted (Null/knockout, Reporter)
Mutation:    Insertion
Mutation detailsA cassette containing a lacZ gene followed by a floxed neo gene was inserted at the start codon in exon 1. RT-PCR and Northern blot analysis of splenic RNA showed an absence of transcript in homozygous mutant mice. Mice heterozygous for this allele were bred with transgenic mice bearing a constitutively expressed cre recombinase gene to generate F2rl3tm1.1Cgh mice. (J:71391)
View phenotypes for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any F2rl3 Mutation:  2 strains or lines available
Original:  J:71391 Sambrano GR, et al., Role of thrombin signalling in platelets in haemostasis and thrombosis. Nature. 2001 Sep 6;413(6851):74-8
All:  14 reference(s)

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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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