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Hivep2tm1Sis
Targeted Allele Detail
Nomenclature
Symbol: Hivep2tm1Sis
Name: human immunodeficiency virus type I enhancer binding protein 2; targeted mutation 1, Shunsuke Ishii
MGI ID: MGI:2182914
Synonyms: Shn-2-
Gene: Hivep2  Location: Chr10:13966075-14151374 bp, + strand  Genetic Position: Chr10, 5.14 cM, cytoband A2
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:72249
Parent Cell Line:  TT2 (ES Cell)
Strain of Origin:  (C57BL/6NCrlj x CBA/JNCrlj)F1
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
 
Mutation detailsA 0.9 kb region of the gene encoding amino acids 1-1713 and containing the N-terminal zinc finger cluster was replaced with a neomycin resistance cassette via homologous recombination. Western blot analysis of T cells from homozygous mutant animals using monoclonal antibodies directed against amino acids 2287-2500 did not detect protein expression. (J:72249)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Disease models
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Expression
In Structures Affected by this Mutation: 8 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 2 strains available      Cell Lines: 0 lines available
Carrying any Hivep2 Mutation:  6 strains or lines available
References
Original:  J:72249 Takagi T, et al., Murine Schnurri-2 is required for positive selection of thymocytes. Nat Immunol. 2001 Nov;2(11):1048-53
All:  13 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
10/08/2019
MGI 6.14
The Jackson Laboratory