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Targeted Allele Detail
Symbol: Ezh2tm1Jnw
Name: enhancer of zeste 2 polycomb repressive complex 2 subunit; targeted mutation 1, Thomas Jenuwein
MGI ID: MGI:2182844
Gene: Ezh2  Location: Chr6:47530274-47595270 bp, - strand  Genetic Position: Chr6, 22.92 cM, cytoband B
Germline Transmission:  Earliest citation of germline transmission: J:69977
Parent Cell Line:  E14.1 (ES Cell)
Strain of Origin:  129P2/OlaHsd
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
Mutation detailsExons 5 and 6 were disrupted by the insertion of a cassette containing lacZ and neo, preventing the transcription of sequence encoding domain II and the carboxy terminal SET domain. Transcript was undetected in homozygous mutant embryos via in situ hybridization. Beta-galactosidase expression was not detected. (J:69977)
View phenotypes and curated references for all genotypes (concatenated display).
In Mice Carrying this Mutation: 2 assay results
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Ezh2 Mutation:  53 strains or lines available
Original:  J:69977 O'Carroll D, et al., The polycomb-group gene Ezh2 is required for early mouse development. Mol Cell Biol. 2001 Jul;21(13):4330-6
All:  1 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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MGI 6.14
The Jackson Laboratory