Lepr^KK
Spontaneous Allele Detail

Summary

• Symbol: Lepr^KK
• Name: leptin receptor; KK
• MGI ID: MGI:2182842
• Synonyms: ASP600Asn
• Gene: Lepr Location: Chr4:101574601-101672549 bp, + strand Genetic Position: Chr4, 46.96 cM
• Alliance: Lepr^KK page

Mutation origin

• Strain of Origin: KK

Mutation description

• Allele Type: Spontaneous
• Mutation: Nucleotide substitutions
• Mutation details: Sequence analysis of the Lepr gene in the hyperinsulinemic KK mouse strain identified a conservative amino acid substitution; Asp(600)Asn in a highly conserved area of the protein. Data suggests that the variant contributes to the obesity phenotype seen in mice, but that the contribution is only part of a multigenic syndrome. (J:53637)

Expression

In Structures Affected by this Mutation:

2 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Lepr Mutation: 121 strains or lines available

References

• Original: J:53637 Igel M, et al., Hyperleptinemia and leptin receptor variant Asp600Asn in the obese, hyperinsulinemic KK mouse strain. J Mol Endocrinol. 1998 Dec;21(3):337-45
• All: 1 reference(s)