Per1^tm1Drw
Targeted Allele Detail

Summary

• Symbol: Per1^tm1Drw
• Name: period circadian clock 1; targeted mutation 1, David R Weaver
• MGI ID: MGI:2182831
• Synonyms: mPer1^ldc, Per1^-, Per1 KO, Per1^m
• Gene: Per1 Location: Chr11:68986043-69000786 bp, + strand Genetic Position: Chr11, 42.37 cM, cytoband B
• Alliance: Per1^tm1Drw page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:69626
• Parent Cell Line: J1 (ES Cell)
• Strain of Origin: 129S4/SvJae

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: Exons 2 through 12 were replaced with a neomycin selection cassette. The deleted region included the translational start site and the basic helix-loop-helix and PAS domains. Normal protein was undetected in homozygous mutant mice by immunohistochemical staining of superchiasmatic nuclei over a 24 hour period. (J:69626)

Disease models

Expression

In Mice Carrying this Mutation:

4 assay results

Tumor Data

List all tumor models in MMHCdb carrying Per1^tm1Drw

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 2 strains available Cell Lines: 0 lines available
• Carrying any Per1 Mutation: 62 strains or lines available

References

• Original: J:69626 Bae K, et al., Differential Functions of mPer1, mPer2, and mPer3 in the SCN Circadian Clock. Neuron. 2001 May;30(2):525-36
• All: 53 reference(s)