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Per1tm1Drw
Targeted Allele Detail
Nomenclature
Symbol: Per1tm1Drw
Name: period circadian clock 1; targeted mutation 1, David R Weaver
MGI ID: MGI:2182831
Synonyms: mPer1ldc, Per1-, Per1 KO, Per1m
Gene: Per1  Location: Chr11:69095217-69109960 bp, + strand  Genetic Position: Chr11, 42.37 cM, cytoband B
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:69626
Parent Cell Line:  J1 (ES Cell)
Strain of Origin:  129S4/SvJae
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
 
Mutation detailsExons 2 through 12 were replaced with a neomycin selection cassette. The deleted region included the translational start site and the basic helix-loop-helix and PAS domains. Normal protein was undetected in homozygous mutant mice by immunohistochemical staining of superchiasmatic nuclei over a 24 hour period. (J:69626)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Disease models
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Expression
In Mice Carrying this Mutation: 4 assay results
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 2 strains available      Cell Lines: 0 lines available
Carrying any Per1 Mutation:  17 strains or lines available
References
Original:  J:69626 Bae K, et al., Differential Functions of mPer1, mPer2, and mPer3 in the SCN Circadian Clock. Neuron. 2001 May;30(2):525-36
All:  39 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
01/14/2020
MGI 6.14
The Jackson Laboratory