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Epb4.2tm1Llp
Targeted Allele Detail
Nomenclature
Symbol: Epb4.2tm1Llp
Name: erythrocyte protein band 4.2; targeted mutation 1, Luanne L Peters
MGI ID: MGI:2182816
Synonyms: 4.2-
Gene: Epb4.2  Location: Chr2:121017891-121037072 bp, - strand  Genetic Position: Chr2, 60.37 cM
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:67412
Parent Cell Line:  E14 (ES Cell)
Strain of Origin:  129P2/OlaHsd
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutation:    Disruption caused by insertion of vector
 
Mutation detailsSequence from exons 4 through 8 was deleted by the insertion of a neomycin selection cassette. Northern blot analysis of total reticulocyte RNA and RNase protection assays of nonerythroid tissue samples did not detect message encoded by the targeted allele. Protein was determined to be absent in erythroid cells from homozygous mutant mice via Western blot analysis and Coomassie blue staining. (J:67412)
Phenotypes
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View phenotypes for all genotypes (concatenated display).
Disease models
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Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Epb4.2 Mutation:  3 strains or lines available
References
Original:  J:67412 Peters LL, et al., Mild spherocytosis and altered red cell ion transport in protein 4. 2-null mice. J Clin Invest. 1999 Jun;103(11):1527-37
All:  4 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
02/25/2015
MGI 5.21
The Jackson Laboratory