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Targeted Allele Detail
Symbol: Epb42tm1Llp
Name: erythrocyte membrane protein band 4.2; targeted mutation 1, Luanne L Peters
MGI ID: MGI:2182816
Synonyms: 4.2-
Gene: Epb42  Location: Chr2:120848372-120867358 bp, - strand  Genetic Position: Chr2, 60.37 cM
Germline Transmission:  Earliest citation of germline transmission: J:67412
Parent Cell Line:  E14 (ES Cell)
Strain of Origin:  129P2/OlaHsd
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
Mutation detailsSequence from exons 4 through 8 was replaced with a neomycin selection cassette. Northern blot analysis of total reticulocyte RNA and RNase protection assays of nonerythroid tissue samples did not detect message encoded by the targeted allele. Protein was determined to be absent in erythroid cells from homozygous mutant mice via Western blot analysis and Coomassie blue staining. (J:67412)
View phenotypes and curated references for all genotypes (concatenated display).
Disease models
In Structures Affected by this Mutation: 2 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Epb42 Mutation:  22 strains or lines available
Original:  J:67412 Peters LL, et al., Mild spherocytosis and altered red cell ion transport in protein 4. 2-null mice. J Clin Invest. 1999 Jun;103(11):1527-37
All:  5 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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MGI 6.20
The Jackson Laboratory