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Ets1tm2Jml
Targeted Allele Detail
Nomenclature
Symbol: Ets1tm2Jml
Name: E26 avian leukemia oncogene 1, 5' domain; targeted mutation 2, Jeffrey M Leiden
MGI ID: MGI:2182780
Synonyms: Ets-1-
Gene: Ets1  Location: Chr9:32636221-32757820 bp, + strand  Genetic Position: Chr9, 17.97 cM
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:50627
Parent Cell Line:  RW-4 (ES Cell)
Strain of Origin:  129X1/SvJ
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
 
Mutation detailsA region encompassing all of exon 3 and a portion of exon 4 was deleted by the insertion of a neomycin selection cassette. Neither normal nor truncated protein was detected via Western blot analysis of splenocyte protein extracts obtained from homozygous mutant mice. (J:50627)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Expression
In Mice Carrying this Mutation: 16 assay results
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Ets1 Mutation:  5 strains or lines available
References
Original:  J:50627 Barton K, et al., The Ets-1 transcription factor is required for the development of natural killer cells in mice. Immunity. 1998 Oct;9(4):555-63
All:  18 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
06/30/2020
MGI 6.15
The Jackson Laboratory