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Rnaseltm1Slvm
Targeted Allele Detail
Nomenclature
Symbol: Rnaseltm1Slvm
Name: ribonuclease L (2', 5'-oligoisoadenylate synthetase-dependent); targeted mutation 1, Robert H Silverman
MGI ID: MGI:2182763
Synonyms: RL-, RNase L-
Gene: Rnasel  Location: Chr1:153749426-153764221 bp, + strand  Genetic Position: Chr1, 65.43 cM, cytoband G2
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:44292
Parent Cell Line:  E14.1 (ES Cell)
Strain of Origin:  129P2/OlaHsd
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutation:    Insertion
 
Mutation detailsExon 1, encoding the activator-binding region, was disrupted at codon 100 by the insertion of a neomycin selection cassette. The absence of normal protein in homozygous mutant mice was determined via Western blot analysis of MEF protein extracts and by binding assays on extracts from various organs. No ribonuclease activity was detected in MEF via Northern blot analysis. (J:44292)
Phenotypes
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Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Rnasel Mutation:  10 strains or lines available
References
Original:  J:44292 Zhou A, et al., Interferon action and apoptosis are defective in mice devoid of 2',5'-oligoadenylate-dependent RNase L. EMBO J. 1997 Nov 3;16(21):6355-63
All:  16 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
11/29/2016
MGI 6.06
The Jackson Laboratory