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Nfatc2tm1Rao
Targeted Allele Detail
Nomenclature
Symbol: Nfatc2tm1Rao
Name: nuclear factor of activated T cells, cytoplasmic, calcineurin dependent 2; targeted mutation 1, Anjana Rao
MGI ID: MGI:2182743
Synonyms: NFAT1-, NFATC2-
Gene: Nfatc2  Location: Chr2:168476410-168601657 bp, - strand  Genetic Position: Chr2, 88.91 cM
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:33105
Parent Cell Line:  Not Specified (ES Cell)
Strain of Origin:  Not Specified
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutation:    Insertion
 
Mutation detailsAn amino terminal exon, encoding residues conserved in DNA-binding domains, was disrutped by the insertion of a PGK-neo cassette. RT-PCR analysis indicated aberrant splicing in which the targeted exon had been excised, resulting in a frameshift mutation that introduced a nonsense mutation at amino acid 438. Protein encoded by the mutant transcript was undetected by several antibodies in extracts from homozygous mutant mice. A DNA-binding assay showed reduced activity in cytosolic extracts of homozygous mutant T cells (the residual activity was attributed to the presence of protein encoded by Nfatc1). (J:33105)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 3 strains available      Cell Lines: 0 lines available
Carrying any Nfatc2 Mutation:  11 strains or lines available
References
Original:  J:33105 Xanthoudakis S, et al., An enhanced immune response in mice lacking the transcription factor NFAT1. Science. 1996 May 10;272(5263):892-5
All:  29 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
09/22/2020
MGI 6.16
The Jackson Laboratory