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Targeted Allele Detail
Symbol: Nfatc2tm1Glm
Name: nuclear factor of activated T cells, cytoplasmic, calcineurin dependent 2; targeted mutation 1, Laurie H Glimcher
MGI ID: MGI:2182740
Synonyms: c2-, NFATc2-, NF-ATp-mut
Gene: Nfatc2  Location: Chr2:168476410-168601657 bp, - strand  Genetic Position: Chr2, 88.91 cM
Germline Transmission:  Earliest citation of germline transmission: J:32728
Parent Cell Line:  Not Specified (ES Cell)
Strain of Origin:  Not Specified
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
Mutation detailsA neomycin selection cassette replaced sequences encoding 47 amino acids of the Rel homology domain. An absence of normal protein in homozygous mutant mice was determined through Western blot analysis. Low levels of reactive polypeptides were present in the cytoplasm, however, no reactivity was observed in the nucleus. RT-PCR and sequence analysis revealed aberrantly spliced in-frame transcripts from which the targeted exon had been excised. An electrophoretic mobility shift assay confirmed that DNA was not binding to the mutant protein. (J:32728)
View phenotypes for all genotypes (concatenated display).
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Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Nfatc2 Mutation:  12 strains or lines available
Original:  J:32728 Hodge MR, et al., Hyperproliferation and dysregulation of IL-4 expression in NF-ATp-deficient mice. Immunity. 1996 Apr;4(4):397-405
All:  33 reference(s)

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MGI 6.01
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