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Targeted Allele Detail
Symbol: Gadd45atm1Ajf
Name: growth arrest and DNA-damage-inducible 45 alpha; targeted mutation 1, Albert J Fornace
MGI ID: MGI:2182720
Synonyms: Gadd45a-
Gene: Gadd45a  Location: Chr6:67035096-67037457 bp, - strand  Genetic Position: Chr6, 30.72 cM
Exencephaly in Brca1tm2.1Cxd/Brca1tm2.1Cxd Gadd45atm1Ajf/Gadd45atm1Ajf embryos

Show the 2 phenotype image(s) involving this allele.

Germline Transmission:  Earliest citation of germline transmission: J:57882
Parent Cell Line:  Other (see notes) (ES Cell)
Strain of Origin:  129
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
Mutation details2.5 kb of the promoter and exons 1-3 were replaced with a PGK-neo cassette via homologous recombination. Absence of gene expression in homozygous mutants was verified by RNase protection assay using an exon 3 probe and mouse embryonic fibroblasts derived from E13.5 homozygous mutant embryos. (J:57882)
View phenotypes for all genotypes (concatenated display).
Disease models
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Gadd45a Mutation:  2 strains or lines available
ES cell line = ESVJ-1183 (129X1/SvJ) or HM-1 (129P2/OlaHsd).

Original:  J:57882 Hollander MC, et al., Genomic instability in Gadd45a-deficient mice. Nat Genet. 1999 Oct;23(2):176-84
All:  22 reference(s)

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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
MGI 5.21
The Jackson Laboratory