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Targeted Allele Detail
Symbol: Il21rtm1Day
Name: interleukin 21 receptor; targeted mutation 1, Debra A Young
MGI ID: MGI:2182707
Synonyms: IL-21R-
Gene: Il21r  Location: Chr7:125603429-125633570 bp, + strand  Genetic Position: Chr7, 68.98 cM, cytoband F4
Impaired allergic skin inflammation and systemic response to epicutaneous sensitization in Il21rtm1Day/Il21rtm1Day mice

Show the 1 phenotype image(s) involving this allele.

Germline Transmission:  Earliest citation of germline transmission: J:76043
Parent Cell Line:  Other (see notes) (ES Cell)
Strain of Origin:  C57BL/6
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
Mutation detailsExon 1 was replaced with a neomycin resistance gene via homologous recombination. Absence of gene expression was verified by PCR of total RNA from homozygous mutant animals. (J:76043)
View phenotypes and curated references for all genotypes (concatenated display).
In Structures Affected by this Mutation: 1 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Il21r Mutation:  25 strains or lines available
ES cell line = J12.
Original:  J:76043 Kasaian MT, et al., IL-21 Limits NK Cell Responses and Promotes Antigen-Specific T Cell Activation. A Mediator of the Transition from Innate to Adaptive Immunity. Immunity. 2002 Apr;16(4):559-69
All:  24 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
MGI 6.16
The Jackson Laboratory