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Hdctm1Nagy
Targeted Allele Detail
Nomenclature
Symbol: Hdctm1Nagy
Name: histidine decarboxylase; targeted mutation 1, Andras Nagy
MGI ID: MGI:2182618
Synonyms: HDC-, HDCdelta6-8, HDC KO
Gene: Hdc  Location: Chr2:126593667-126619299 bp, - strand  Genetic Position: Chr2, 61.76 cM, cytoband E5-G
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:70702
Parent Cell Line:  R1 (ES Cell)
Strain of Origin:  (129X1/SvJ x 129S1/Sv)F1-Kitl+
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
 
Mutation detailsA portion of the gene from intron 5 to exon 9 was replaced with a PGK-neo cassette via homologous recombination resulting in the deletion of the coenzyme binding site encoded by exon 8. Northern blot analysis of kidneys from homozygous mutant animals verified the absence of gene expression. (J:70702)
Phenotypes
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View phenotypes for all genotypes (concatenated display).
Disease models
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Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Hdc Mutation:  22 strains or lines available
References
Original:  J:70702 Ohtsu H, et al., Mice lacking histidine decarboxylase exhibit abnormal mast cells. FEBS Lett. 2001 Jul 27;502(1-2):53-6
All:  73 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
09/13/2016
MGI 6.05
The Jackson Laboratory