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Targeted Allele Detail
Symbol: Hdctm1Nagy
Name: histidine decarboxylase; targeted mutation 1, Andras Nagy
MGI ID: MGI:2182618
Synonyms: HDC-, HDCdelta6-8, HDC KO
Gene: Hdc  Location: Chr2:126593667-126619299 bp, - strand  Genetic Position: Chr2, 61.76 cM, cytoband E5-G
Germline Transmission:  Earliest citation of germline transmission: J:70702
Parent Cell Line:  R1 (ES Cell)
Strain of Origin:  (129X1/SvJ x 129S1/Sv)F1-Kitl+
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
Mutation detailsA portion of the gene from intron 5 to exon 9 was replaced with a PGK-neo cassette via homologous recombination resulting in the deletion of the coenzyme binding site encoded by exon 8. Northern blot analysis of kidneys from homozygous mutant animals verified the absence of gene expression. (J:70702)
View phenotypes and curated references for all genotypes (concatenated display).
Disease models
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Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Hdc Mutation:  34 strains or lines available
Original:  J:70702 Ohtsu H, et al., Mice lacking histidine decarboxylase exhibit abnormal mast cells. FEBS Lett. 2001 Jul 27;502(1-2):53-6
All:  75 reference(s)

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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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MGI 6.11
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