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Targeted Allele Detail
Symbol: Krt5tm1Tmm
Name: keratin 5; targeted mutation 1, Thomas M Magin
MGI ID: MGI:2182612
Synonyms: K5-
Gene: Krt5  Location: Chr15:101707070-101712891 bp, - strand  Genetic Position: Chr15, 56.98 cM
Germline Transmission:  Earliest citation of germline transmission: J:76311
Parent Cell Line:  HM-1 (ES Cell)
Strain of Origin:  129P2/OlaHsd-Hprtb-m3
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
Mutation detailsThe promoter and first 2 exons were replaced with an Hprt cassette via homologous recombination. Northern blot of homozygous mutant animals showed complete absence of gene expression. Western blot analysis of skin protein extracts from homozygous mutants showed lack of protein expression. (J:76311)
View phenotypes for all genotypes (concatenated display).
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Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Krt5 Mutation:  3 strains or lines available
Original:  J:76311 Peters B, et al., Complete cytolysis and neonatal lethality in keratin 5 knockout mice reveal its fundamental role in skin integrity and in epidermolysis bullosa simplex. Mol Biol Cell. 2001 Jun;12(6):1775-89
All:  5 reference(s)

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MGI 6.01
The Jackson Laboratory