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Efna5tm1Ddmo
Targeted Allele Detail
Nomenclature
Symbol: Efna5tm1Ddmo
Name: ephrin A5; targeted mutation 1, Dennis D M O'Leary
MGI ID: MGI:2182573
Synonyms: A5-, eA5KO, ephrin-A5-
Gene: Efna5  Location: Chr17:62604184-62881317 bp, - strand  Genetic Position: Chr17, 32.57 cM
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:45896
Parent Cell Line:  R1 (ES Cell)
Strain of Origin:  (129X1/SvJ x 129S1/Sv)F1-Kitl+
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
 
Mutation detailsA neomycin selection cassette replaced sequence encoding amino acids 42 through 129 as well as a 5' splice acceptor. RT-PCR analysis showed an absence of transcript in homozygous mutant mice. (J:45896)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Disease models
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Expression
In Structures Affected by this Mutation: 3 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Efna5 Mutation:  18 strains or lines available
References
Original:  J:45896 Frisen J, et al., Ephrin-A5 (AL-1/RAGS) is essential for proper retinal axon guidance and topographic mapping in the mammalian visual system. Neuron. 1998 Feb;20(2):235-43
All:  43 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
06/12/2018
MGI 6.12
The Jackson Laboratory