Adra1d^tm1Gzt
Targeted Allele Detail

Summary

• Symbol: Adra1d^tm1Gzt
• Name: adrenergic receptor, alpha 1d; targeted mutation 1, Gozoh Tsujimoto
• MGI ID: MGI:2182469
• Synonyms: alpha1D^-, alpha1d-AR^-, alpha1D-KO
• Gene: Adra1d Location: Chr2:131387770-131404203 bp, - strand Genetic Position: Chr2, 63.5 cM
• Alliance: Adra1d^tm1Gzt page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:75628
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: 129/Sv

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A 0.3 kb fragment of exon 1, which includes the translation initiation codon, was replaced with a PGK-neo cassette via homologous recombination. The knockout allele was confirmed by RT-PCR analysis of various tissues from homozygous mutant animals. No gene expression was detected. (J:75628)

Expression

In Structures Affected by this Mutation:

4 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Adra1d Mutation: 30 strains or lines available

References

• Original: J:75628 Tanoue A, et al., The alpha(1D)-adrenergic receptor directly regulates arterial blood pressure via vasoconstriction. J Clin Invest. 2002 Mar;109(6):765-75
• All: 16 reference(s)