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Kcnj10tm1Lst
Targeted Allele Detail
Nomenclature
Symbol: Kcnj10tm1Lst
Name: potassium inwardly-rectifying channel, subfamily J, member 10; targeted mutation 1, Henry A Lester
MGI ID: MGI:2182467
Synonyms: Kcnj10tm1Pkj, Kir4.1-
Gene: Kcnj10  Location: Chr1:172341210-172374085 bp, + strand  Genetic Position: Chr1, 79.69 cM
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:63635
Parent Cell Line:  CJ7 (ES Cell)
Strain of Origin:  129S1/Sv-Oca2+ Tyr+ Kitl+
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
 
Mutation detailsThe coding exon of the gene encoding amino acids 33-266, which includes part of the C-terminus and putative transmembrane domains, was replaced with a PGK-neo cassette via homologous recombination. Northern blot analysis of retinas from homozygous mutant animals did not detect gene expression. (J:63635)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Disease models
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Expression
In Structures Affected by this Mutation: 17 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Kcnj10 Mutation:  17 strains or lines available
References
Original:  J:63635 Kofuji P, et al., Genetic inactivation of an inwardly rectifying potassium channel (Kir4.1 subunit) in mice: phenotypic impact in retina. J Neurosci. 2000 Aug 1;20(15):5733-40
All:  16 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
07/03/2018
MGI 6.12
The Jackson Laboratory