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Targeted Allele Detail
Symbol: Kcnj10tm1Lst
Name: potassium inwardly-rectifying channel, subfamily J, member 10; targeted mutation 1, Henry A Lester
MGI ID: MGI:2182467
Synonyms: Kcnj10tm1Pkj, Kir4.1-
Gene: Kcnj10  Location: Chr1:172341210-172374085 bp, + strand  Genetic Position: Chr1, 79.69 cM
Germline Transmission:  Earliest citation of germline transmission: J:63635
Parent Cell Line:  CJ7 (ES Cell)
Strain of Origin:  129S1/Sv-Oca2+ Tyr+ Kitl+
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
Mutation detailsThe coding exon of the gene encoding amino acids 33-266, which includes part of the C-terminus and putative transmembrane domains, was replaced with a PGK-neo cassette via homologous recombination. Northern blot analysis of retinas from homozygous mutant animals did not detect gene expression. (J:63635)
View phenotypes and curated references for all genotypes (concatenated display).
Disease models
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Kcnj10 Mutation:  17 strains or lines available
Original:  J:63635 Kofuji P, et al., Genetic inactivation of an inwardly rectifying potassium channel (Kir4.1 subunit) in mice: phenotypic impact in retina. J Neurosci. 2000 Aug 1;20(15):5733-40
All:  16 reference(s)

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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
MGI 6.11
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