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Dnmt1tm1Pwl
Targeted Allele Detail
Summary
Symbol: Dnmt1tm1Pwl
Name: DNA methyltransferase 1; targeted mutation 1, Peter W Laird
MGI ID: MGI:2182453
Synonyms: Dnmt1R, DnmtR
Gene: Dnmt1  Location: Chr9:20818501-20871084 bp, - strand  Genetic Position: Chr9, 7.66 cM
Alliance: Dnmt1tm1Pwl page
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:75230
Parent Cell Line:  J1 (ES Cell)
Strain of Origin:  129S4/SvJae
Mutation
description
Allele Type:    Targeted (Hypomorph)
Mutation:    Insertion
 
Mutation detailsA hypomorphic allele was generated by the insertion of the operater sequence (lacO) from the lac operon in intron 3 via recombinatory techniques. Quantitation of Northern blot analysis results showed a 40% reduction in transcript levels versus wild-type. (J:75230)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Tumor Data
List all tumor models in MMHCdb carrying Dnmt1tm1Pwl
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Dnmt1 Mutation:  108 strains or lines available
References
Original:  J:75230 Eads CA, et al., Complete Genetic Suppression of Polyp Formation and Reduction of CpG-Island Hypermethylation in Apc(Min/+) Dnmt1-Hypomorphic Mice. Cancer Res. 2002 Mar 1;62(5):1296-9
All:  5 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
03/12/2024
MGI 6.23
The Jackson Laboratory