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Targeted Allele Detail
Symbol: Dnmt1tm1Pwl
Name: DNA methyltransferase (cytosine-5) 1; targeted mutation 1, Peter W Laird
MGI ID: MGI:2182453
Synonyms: Dnmt1R, DnmtR
Gene: Dnmt1  Location: Chr9:20907209-20959888 bp, - strand  Genetic Position: Chr9, 7.66 cM
Germline Transmission:  Earliest citation of germline transmission: J:75230
Parent Cell Line:  J1 (ES Cell)
Strain of Origin:  129S4/SvJae
Allele Type:    Targeted (Hypomorph)
Mutation:    Insertion
Mutation detailsA hypomorphic allele was generated by the insertion of the operater sequence (lacO) from the lac operon in intron 3 via recombinatory techniques. Quantitation of Northern blot analysis results showed a 40% reduction in transcript levels versus wild-type. (J:75230)
View phenotypes and curated references for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Dnmt1 Mutation:  76 strains or lines available
Original:  J:75230 Eads CA, et al., Complete Genetic Suppression of Polyp Formation and Reduction of CpG-Island Hypermethylation in Apc(Min/+) Dnmt1-Hypomorphic Mice. Cancer Res. 2002 Mar 1;62(5):1296-9
All:  5 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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MGI 6.12
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