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Dmtf1tm1Cjs
Targeted Allele Detail
Nomenclature
Symbol: Dmtf1tm1Cjs
Name: cyclin D binding myb-like transcription factor 1; targeted mutation 1, Charles J Sherr
MGI ID: MGI:2182441
Synonyms: DMP1-
Gene: Dmtf1  Location: Chr5:9118801-9161776 bp, - strand  Genetic Position: Chr5, 3.69 cM, cytoband A2-A3
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:63444
Parent Cell Line:  Not Specified (ES Cell)
Strain of Origin:  Not Specified
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutation:    Insertion
 
Mutation detailsExons encoding residues involved in DNA-binding were disrupted by the insertion of a 1.0kb neomycin selection cassette. Western blot analysis using antibodies raised against the carboxy terminal and the Myb-repeat domain showed an absence of encoded protein in homozygous mutant mice. (J:63444)
Phenotypes
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Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Dmtf1 Mutation:  33 strains or lines available
References
Original:  J:63444 Inoue K, et al., Disruption of the ARF transcriptional activator DMP1 facilitates cell immortalization, Ras transformation, and tumorigenesis. Genes Dev. 2000 Jul 15;14(14):1797-809
All:  5 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
04/21/2015
MGI 5.21
The Jackson Laboratory