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Targeted Allele Detail
Symbol: Dnmt3btm1Enl
Name: DNA methyltransferase 3B; targeted mutation 1, En Li
MGI ID: MGI:2182409
Gene: Dnmt3b  Location: Chr2:153649450-153687730 bp, + strand  Genetic Position: Chr2, 75.79 cM, cytoband A2-A3
Germline Transmission:  Earliest citation of germline transmission: J:58298
Parent Cell Line:  J1 (ES Cell)
Strain of Origin:  129S4/SvJae
Allele Type:    Targeted (Null/knockout, Reporter)
Mutations:    Insertion, Intragenic deletion
Mutation detailsA 2.4kb region encoding the PC and ENV motifs was replaced with a cassette containing IRES-lacZ and neo. Northern blot analysis of total RNA showed transcript levels to be reduced in heterozygous mice. X-gal staining of heterozygous embryos revealed expression of beta-galactosidase. (J:58298)
View phenotypes and curated references for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Dnmt3b Mutation:  30 strains or lines available
Original:  J:58298 Okano M, et al., DNA methyltransferases Dnmt3a and Dnmt3b are essential for de novo methylation and mammalian development. Cell. 1999 Oct 29;99(3):247-57
All:  7 reference(s)

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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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MGI 6.10
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