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Ncam1tm2Mag
Targeted Allele Detail
Nomenclature
Symbol: Ncam1tm2Mag
Name: neural cell adhesion molecule 1; targeted mutation 2, Terry Magnuson
MGI ID: MGI:2182407
Gene: Ncam1  Location: Chr9:49502136-49798925 bp, - strand  Genetic Position: Chr9, 26.83 cM
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:34293
Parent Cell Line:  Other (see notes) (ES Cell)
Strain of Origin:  129
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
 
Mutation detailsA PGK-neomycin resistance cassette replaced 500 bp of sequence including exon 13. Exon 13 is a nonalternatively spliced exon that encodes part of the second fibronectin type III repeat in the extracellular domain. The authors predict that this allele would produce a truncated product. (J:34293)
Phenotypes
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View phenotypes for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Ncam1 Mutation:  24 strains or lines available
Notes
ES cell line = D3 (129S2/SvPas), R1 ((129X1/SvJ x 129S1/Sv)F1-Kitl+), or CT1 (129/Sv, subline not specified).
References
Original:  J:34293 Rabinowitz JE, et al., Targeted mutation of Ncam to produce a secreted molecule results in a dominant embryonic lethality. Proc Natl Acad Sci U S A. 1996 Jun 25;93(13):6421-4
All:  1 reference(s)

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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
08/23/2016
MGI 6.05
The Jackson Laboratory