Ncam1^tm2Mag
Targeted Allele Detail

Summary

• Symbol: Ncam1^tm2Mag
• Name: neural cell adhesion molecule 1; targeted mutation 2, Terry Magnuson
• MGI ID: MGI:2182407
• Gene: Ncam1 Location: Chr9:49413436-49710225 bp, - strand Genetic Position: Chr9, 26.83 cM
• Alliance: Ncam1^tm2Mag page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:34293
• Parent Cell Line: Other (see notes) (ES Cell)
• Strain of Origin: 129

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A PGK-neomycin resistance cassette replaced 500 bp of sequence including exon 13. Exon 13 is a nonalternatively spliced exon that encodes part of the second fibronectin type III repeat in the extracellular domain. The authors predict that this allele would produce a truncated product. (J:34293)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Ncam1 Mutation: 65 strains or lines available

Notes

ES cell line = D3 (129S2/SvPas), R1 ((129X1/SvJ x 129S1/Sv)F1-Kitl⁺), or CT1 (129/Sv, subline not specified).

References

• Original: J:34293 Rabinowitz JE, et al., Targeted mutation of Ncam to produce a secreted molecule results in a dominant embryonic lethality. Proc Natl Acad Sci U S A. 1996 Jun 25;93(13):6421-4
• All: 1 reference(s)