Mnx1^tm1Tmj
Targeted Allele Detail

Summary

• Symbol: Mnx1^tm1Tmj
• Name: motor neuron and pancreas homeobox 1; targeted mutation 1, Thomas M Jessell
• MGI ID: MGI:2182358
• Synonyms: Hb9^-, Hb9^nlslacZ, Hlxb9^nlslacZ
• Gene: Mnx1 Location: Chr5:29678821-29683468 bp, - strand Genetic Position: Chr5, 15.04 cM
• Alliance: Mnx1^tm1Tmj page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:57340
• Parent Cell Line: W9.5/W95 (ES Cell)
• Strain of Origin: 129S1/Sv-Oca2⁺ Tyr⁺ Kitl⁺

Mutation description

• Allele Type: Targeted (Null/knockout, Reporter)
• Mutation: Insertion
• Mutation details: Exon 1 was disrupted by the insertion of a cassette containing an IRES-nls-lacZ gene, a floxed neomycin gene, and a SV40 polyadenylation signal. The absence of encoded protein in the spinal cords of homozygous mutant embryos was determined using antisera for both the amino and carboxy termini. Staining of heterozygotes showed the expression pattern of beta-galactosidase to be similar to that of the endogenous gene. (J:57340)

Expression

In Structures Affected by this Mutation:

4 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Mnx1 Mutation: 28 strains or lines available

References

• Original: J:57340 Arber S, et al., Requirement for the homeobox gene Hb9 in the consolidation of motor neuron identity. Neuron. 1999 Aug;23(4):659-74
• All: 6 reference(s)