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Targeted Allele Detail
Symbol: Cyp1a2tm1Dwn
Name: cytochrome P450, family 1, subfamily a, polypeptide 2; targeted mutation 1, Daniel W Nebert
MGI ID: MGI:2182351
Synonyms: Cyp1a2-, HPRT KO BS-CL
Gene: Cyp1a2  Location: Chr9:57584220-57590938 bp, - strand  Genetic Position: Chr9, 31.3 cM
Dioxin-induced hepatic injury in Cyp1a1tm1.1Dwn/Cyp1a1tm1.1Dwn and Cyp1a2tm1Dwn/Cyp1a2tm1Dwn mice

Show the 1 phenotype image(s) involving this allele.

Germline Transmission:  Earliest citation of germline transmission: J:31730
Parent Cell Line:  E14TG2a (ES Cell)
Strain of Origin:  129P2/OlaHsd
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
Mutation detailsThe insertion of an hprt gene, with the opposite orientation of the endogenous gene, deleted a portion of exon 2 and all of exons 3 through 5. This deleted region encoded the conserved cysteine-containing fragment and the cytochrome P450 tridecapeptide. Northern blot analysis of total hepatic RNA obtained from beta-naphthoflavone-treated animals showed a lack of transcript in homozygous mutant mice. Failure of homozygous mutant mice to metabolize zoxazolamine, a muscle relaxant, indicated a lack of functional protein. (J:31730)
View phenotypes and curated references for all genotypes (concatenated display).
In Structures Affected by this Mutation: 1 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Cyp1a2 Mutation:  23 strains or lines available
Original:  J:31730 Liang HC, et al., Cyp1a2(-/-) null mutant mice develop normally but show deficient drug metabolism. Proc Natl Acad Sci U S A. 1996 Feb 20;93(4):1671-6
All:  29 reference(s)

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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
MGI 6.17
The Jackson Laboratory