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Cyp24a1tm1Star
Targeted Allele Detail
Nomenclature
Symbol: Cyp24a1tm1Star
Name: cytochrome P450, family 24, subfamily a, polypeptide 1; targeted mutation 1, Rene St-Arnaud
MGI ID: MGI:2182338
Synonyms: 24-OHase
Gene: Cyp24a1  Location: Chr2:170482957-170497145 bp, - strand  Genetic Position: Chr2, 91.91 cM
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:56453
Parent Cell Line:  J1 (ES Cell)
Strain of Origin:  129S4/SvJae
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
 
Mutation detailsExons 9 and 10, the latter encoding the heme-binding domain, were replaced with a PGK-neo selection cassette. Transcript was reported to be undetectable in homozygous mutant mice. Neither an immunoassay nor HPLC fractionation followed by a competitive binding assay could detect the enzymatic product, 24,25-dihydroxyvitamin D, of the encoded protein in homozygous mutant mice. (J:63457)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Expression
In Structures Affected by this Mutation: 5 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Cyp24a1 Mutation:  10 strains or lines available
References
Original:  J:56453 St-Arnaud R, Targeted inactivation of vitamin D hydroxylases in mice. Bone. 1999 Jul;25(1):127-9
All:  7 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
02/11/2020
MGI 6.14
The Jackson Laboratory