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Targeted Allele Detail
Symbol: Cysltr1tm1Ykn
Name: cysteinyl leukotriene receptor 1; targeted mutation 1, Yoshihide Kanaoka
MGI ID: MGI:2182326
Synonyms: CysLT1R-, Cys-LT1R KO
Gene: Cysltr1  Location: ChrX:106576509-106603679 bp, - strand  Genetic Position: ChrX, 47.36 cM, cytoband D
Germline Transmission:  Earliest citation of germline transmission: J:77087
Parent Cell Line:  V26.2 (ES Cell)
Strain of Origin:  C57BL/6
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
Mutation detailsA 278 bp coding region of exon 4 common to both the long and short isoforms of the gene was replaced with a neomycin resistance gene via homologous recombination. Northern blot analysis verified the absence of gene expression in lung of homozygous mutant animals. (J:77087)
View phenotypes and curated references for all genotypes (concatenated display).
In Structures Affected by this Mutation: 3 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 2 strains available      Cell Lines: 0 lines available
Carrying any Cysltr1 Mutation:  3 strains or lines available
Original:  J:77087 Maekawa A, et al., Targeted gene disruption reveals the role of cysteinyl leukotriene 1 receptor in the enhanced vascular permeability of mice undergoing acute inflammatory responses. J Biol Chem. 2002 Jun 7;277(23):20820-4
All:  17 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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MGI 6.14
The Jackson Laboratory