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Transgenic Allele Detail
Symbol: Gtf2ird1Tg(Alb1-Myc)166.8Sst
Name: general transcription factor II I repeat domain-containing 1; transgene insertion 166.8, Snorri S Thorgeirsson
MGI ID: MGI:2182322
Synonyms: Alb-c-myc line 166.8, Alb/c-myc line 166.8, c-myc line 166.8, Gtf2ird1-, Tg(Alb1-Myc)166.8Sst
Gene: Gtf2ird1  Location: Chr5:134357656-134456716 bp, - strand  Genetic Position: Chr5, 74.55 cM
Strain of Origin:  (C57BL/6 x CBA/J)F2
Transgene Type:    Transgenic (Hypomorph, Inserted expressed sequence)
Mutations:    Insertion, Intergenic deletion
Gtf2ird1Tg(Alb1-Myc)166.8Sst expresses 1 gene
Mutation detailsA transgene construct consisting of mouse Myc under the control of the mouse albumin promoter replaced of approximately 40 kb of chromosome 5, encompassing sequence downstream of Cyln2 through the first exon of Gtf2ird1. Northern blot and RT-PCR analysis of heart, muscle, liver, and spleen tissue from homozygous mutant mice showed highly reduced levels of Gtf2ird1 transcript. (J:4527, J:68983)
View phenotypes for all genotypes (concatenated display).
Disease models
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Gtf2ird1 Mutation:  321 strains or lines available
Integration was mapped to a region on chromosome 5 that is orthologous to a human region hemizygously deleted in Williams-Beuren syndrome patients.

Original:  J:4527 Murakami H, et al., Transgenic mouse model for synergistic effects of nuclear oncogenes and growth factors in tumorigenesis: interaction of c-myc and transforming growth factor alpha in hepatic oncogenesis. Cancer Res. 1993 Apr 15;53(8):1719-23
All:  25 reference(s)

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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
MGI 6.03
The Jackson Laboratory