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Lta/Tnftm1Eug
Targeted Allele Detail
Nomenclature
Symbol: Lta/Tnftm1Eug
Name: tumor necrosis factor; targeted mutation 1, Hans-Pietro Eugster
MGI ID: MGI:2182273
Synonyms: TNF-LTalpha-, TNF/LTalpha-, tnf/ltatm1
Gene: Tnf  Location: Chr17:35199381-35202007 bp, - strand  Genetic Position: Chr17, 18.59 cM
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:31129
Parent Cell Line:  GS1 (ES Cell)
Strain of Origin:  129/Sv
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intergenic deletion
 
Mutation detailsThe insertion of a single neomycin selection cassette deleted exons 2 and 3 of the Lta locus and exon 1 through the middle of exon 4 of the Tnf locus. (J:31129)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Expression
In Structures Affected by this Mutation: 10 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Tnf Mutation:  36 strains or lines available
References
Original:  J:31129 Eugster HP, et al., Multiple immune abnormalities in tumor necrosis factor and lymphotoxin-alpha double-deficient mice. Int Immunol. 1996 Jan;8(1):23-36
All:  35 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
02/11/2020
MGI 6.14
The Jackson Laboratory