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Targeted Allele Detail
Symbol: Il6tm1Mur
Name: interleukin 6; targeted mutation 1, Richard Murray
MGI ID: MGI:2182222
Gene: Il6  Location: Chr5:30013114-30019975 bp, + strand  Genetic Position: Chr5, 15.7 cM
Germline Transmission:  Earliest citation of germline transmission: J:25684
Parent Cell Line:  E14.1 (ES Cell)
Strain of Origin:  129P2/OlaHsd
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
Mutation detailsA neomycin selection cassette replaced approximately 95% of exon 4. ELISA, both in vitro of thymic stromal cell supernatants stimulated by LPS and in vivo of sera from LPS stimulated animals, showed a lack of encoded protein in homozygous mutant mice. (J:25684)
View phenotypes and curated references for all genotypes (concatenated display).
In Structures Affected by this Mutation: 4 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Il6 Mutation:  26 strains or lines available
Original:  J:25684 Dalrymple SA, et al., Interleukin-6-deficient mice are highly susceptible to Listeria monocytogenes infection: correlation with inefficient neutrophilia. Infect Immun. 1995 Jun;63(6):2262-8
All:  11 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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MGI 6.15
The Jackson Laboratory