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Targeted Allele Detail
Symbol: Vdac3tm1Wjc
Name: voltage-dependent anion channel 3; targeted mutation 1, Willam J Craigen
MGI ID: MGI:2182182
Synonyms: VDAC3(-)
Gene: Vdac3  Location: Chr8:22577086-22593758 bp, - strand  Genetic Position: Chr8, 11.42 cM
Structural abnormalities in sperm of Vdac3tm1Wjc/Vdac3tm1Wjc male mice

Show the 3 phenotype image(s) involving this allele.

Germline Transmission:  Earliest citation of germline transmission: J:72188
Parent Cell Line:  Not Specified (ES Cell)
Strain of Origin:  Not Specified
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
Mutation detailsThe last four exons were replaced with a neomycin selection cassette. Transcript was undetected in homozygous mutant mice via Northern blot analysis of various tissues. The absence of protein in homozygous mutant mice was demonstrated by Western blot analysis of various tissues and immunohistochemical staining of the testes. (J:72188, J:78058)
View phenotypes for all genotypes (concatenated display).
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Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Vdac3 Mutation:  10 strains or lines available
Original:  J:72188 Sampson MJ, et al., Immotile sperm and infertility in mice lacking mitochondrial voltage-dependent anion channel type 3. J Biol Chem. 2001 Oct 19;276(42):39206-12
All:  6 reference(s)

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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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MGI 6.06
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