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Ncantm3Ref
Targeted Allele Detail
Nomenclature
Symbol: Ncantm3Ref
Name: neurocan; targeted mutation 3, Reinhard Fassler
MGI ID: MGI:2182151
Synonyms: NCCre
Gene: Ncan  Location: Chr8:70093085-70120873 bp, - strand  Genetic Position: Chr8, 34.15 cM
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:70858
Parent Cell Line:  R1 (ES Cell)
Strain of Origin:  (129X1/SvJ x 129S1/Sv)F1-Kitl+
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
 
Mutation detailsA region encompassing the TATA box, the transcription initiation site, and exons 1 and 2 was replaced with a floxed neo cassette that was subsequently excised via the in vitro expression of cre recombinase. Northern and Western blot analyses showed an absence of transcript and protein in homozygous mutant mice. (J:70858)
Phenotypes
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View phenotypes for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Ncan Mutation:  19 strains or lines available
References
Original:  J:70858 Zhou XH, et al., Neurocan is dispensable for brain development. Mol Cell Biol. 2001 Sep;21(17):5970-8
All:  3 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
09/27/2016
MGI 6.05
The Jackson Laboratory