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Targeted Allele Detail
Symbol: Ncantm3Ref
Name: neurocan; targeted mutation 3, Reinhard Fassler
MGI ID: MGI:2182151
Synonyms: NCCre
Gene: Ncan  Location: Chr8:70093085-70120863 bp, - strand  Genetic Position: Chr8, 34.15 cM
Germline Transmission:  Earliest citation of germline transmission: J:70858
Parent Cell Line:  R1 (ES Cell)
Strain of Origin:  (129X1/SvJ x 129S1/Sv)F1-Kitl+
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
Mutation detailsA region encompassing the TATA box, the transcription initiation site, and exons 1 and 2 was replaced with a floxed neo cassette that was subsequently excised via the in vitro expression of cre recombinase. Northern and Western blot analyses showed an absence of transcript and protein in homozygous mutant mice. (J:70858)
View phenotypes and curated references for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Ncan Mutation:  5 strains or lines available
Original:  J:70858 Zhou XH, et al., Neurocan is dispensable for brain development. Mol Cell Biol. 2001 Sep;21(17):5970-8
All:  4 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
MGI 6.14
The Jackson Laboratory