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Targeted Allele Detail
Symbol: Ncantm1Ref
Name: neurocan; targeted mutation 1, Reinhard Fassler
MGI ID: MGI:2182148
Synonyms: NCIg
Gene: Ncan  Location: Chr8:70093085-70120863 bp, - strand  Genetic Position: Chr8, 34.15 cM
Germline Transmission:  Earliest citation of germline transmission: J:70858
Parent Cell Line:  R1 (ES Cell)
Strain of Origin:  (129X1/SvJ x 129S1/Sv)F1-Kitl+
Allele Type:    Targeted (Null/knockout)
Mutation:    Insertion
Mutation detailsA neomycin selection cassette was inserted into exon 3, which encodes the immunoglobulin-like domain. Transcript was detected in homozygous mutant mice via Norhtern blot analysis. RT-PCR revealed that the detected signal was that of an aberrant transcript from which exon 3 had been excised. Western blot analysis showed an absence of protein. (J:70858)
View phenotypes and curated references for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Ncan Mutation:  5 strains or lines available
Original:  J:70858 Zhou XH, et al., Neurocan is dispensable for brain development. Mol Cell Biol. 2001 Sep;21(17):5970-8
All:  1 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
MGI 6.14
The Jackson Laboratory